Ontology highlight
ABSTRACT:
SUBMITTER: Mamasoula C
PROVIDER: S-EPMC3855044 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Mamasoula Chrysovalanto C Prentice R Reid RR Pierscionek Tomasz T Pangilinan Faith F Mills James L JL Druschel Charlotte C Pass Kenneth K Russell Mark W MW Hall Darroch D Töpf Ana A Brown Danielle L DL Zelenika Diana D Bentham Jamie J Cosgrove Catherine C Bhattacharya Shoumo S Riveron Javier Granados JG Setchfield Kerry K Brook J David JD Bu'Lock Frances A FA Thornborough Chris C Rahman Thahira J TJ Doza Julian Palomino JP Tan Huay L HL O'Sullivan John J Stuart A Graham AG Blue Gillian G Winlaw David D Postma Alex V AV Mulder Barbara J M BJ Zwinderman Aelko H AH van Engelen Klaartje K Moorman Antoon F M AF Rauch Anita A Gewillig Marc M Breckpot Jeroen J Devriendt Koen K Lathrop G Mark GM Farrall Martin M Goodship Judith A JA Cordell Heather J HJ Brody Lawrence C LC Keavney Bernard D BD
Circulation. Cardiovascular genetics 20130722 4
<h4>Background</h4>Association between the C677T polymorphism of the methylene tetrahydrofolate reductase (MTHFR) gene and congenital heart disease (CHD) is contentious.<h4>Methods and results</h4>We compared genotypes between CHD cases and controls and between mothers of CHD cases and controls. We placed our results in context by conducting meta-analyses of previously published studies. Among 5814 cases with primary genotype data and 10 056 controls, there was no evidence of association between ...[more]