Ontology highlight
ABSTRACT:
SUBMITTER: Luber S
PROVIDER: S-EPMC3855085 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Luber Sandra S Leung Sophie S Herrmann Carmen C Du Wenge Han WH Noodleman Louis L Batista Victor S VS
Dalton transactions (Cambridge, England : 2003) 20140101 2
Ribonucleotide reductases (RNRs) catalyze the reduction of ribonucleotides into deoxyribonucleotides necessary for DNA biosynthesis. Unlike the conventional class Ia RNRs which use a diiron cofactor in their subunit R2, the active site of the RNR-R2 from Chlamydia trachomatis (Ct) contains a Mn/Fe cofactor. The detailed structure of the Mn/Fe core has yet to be established. In this paper we evaluate six different structural models of the Ct RNR active site in the Mn(iv)/Fe(iii) state by using Mö ...[more]