Ontology highlight
ABSTRACT:
SUBMITTER: Vanhooren V
PROVIDER: S-EPMC3855152 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Vanhooren Valerie V Vandenbroucke Roosmarijn E RE Dewaele Sylviane S Van Hamme Evelien E Haigh Jody J JJ Hochepied Tino T Libert Claude C
PloS one 20131205 12
Glycosylation is an essential post-translational modification, which determines the function of proteins and important processes such as inflammation. β-1,4-galactosyltransferase I (βGalT1) is a key enzyme involved in the addition of galactose moieties to glycoproteins. Intestinal mucins are glycoproteins that protect the gut barrier against invading pathogens and determine the composition of the intestinal microbiota. Proper glycosylation of mucus is important in this regard. By using ubiquitou ...[more]