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Structural insights into RbmA, a biofilm scaffolding protein of V. cholerae.


ABSTRACT: V. cholerae can form sessile biofilms associated with abiotic surfaces, cyanobacteria, zoo-plankton, mollusks, or crustaceans. Along with the vibrio polysaccharide, secreted proteins of the rbm gene cluster are key to the biofilm ultrastructure. Here we provide a thorough structural characterization of RbmA, a protein involved in mediating cell-cell and cell-biofilm contacts. We correlate our structural findings with initial ligand specificity screening results, NMR protein-ligand interaction analysis, and complement our results with a full biocomputational study.

SUBMITTER: Maestre-Reyna M 

PROVIDER: S-EPMC3855419 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Structural insights into RbmA, a biofilm scaffolding protein of V. cholerae.

Maestre-Reyna Manuel M   Wu Wen-Jin WJ   Wang Andrew H-J AH  

PloS one 20131205 12


V. cholerae can form sessile biofilms associated with abiotic surfaces, cyanobacteria, zoo-plankton, mollusks, or crustaceans. Along with the vibrio polysaccharide, secreted proteins of the rbm gene cluster are key to the biofilm ultrastructure. Here we provide a thorough structural characterization of RbmA, a protein involved in mediating cell-cell and cell-biofilm contacts. We correlate our structural findings with initial ligand specificity screening results, NMR protein-ligand interaction an  ...[more]

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