Ontology highlight
ABSTRACT:
SUBMITTER: Althagafy HS
PROVIDER: S-EPMC3855429 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Althagafy Hanan S HS Meza-Aviña Maria Elena ME Oberlies Nicholas H NH Croatt Mitchell P MP
The Journal of organic chemistry 20130722 15
The mechanism for the biomimetic synthesis of flavonolignan diastereoisomers in milk thistle is proposed to proceed by single-electron oxidation of coniferyl alcohol, subsequent reaction with one of the oxygen atoms of taxifolin's catechol moiety, and finally, further oxidation to form four of the major components of silymarin: silybin A, silybin B, isosilybin A, and isosilybin B. This mechanism is significantly different from a previously proposed process that involves the coupling of two indep ...[more]