Association between maternal folate concentrations during pregnancy and insulin resistance in Indian children.

ABSTRACT:

Aims/hypothesis

In an Indian birth cohort, higher maternal homocysteine concentration in pregnancy was associated with lower birthweight of the offspring. Lower maternal vitamin B12 and higher folate concentrations were associated with higher offspring insulin resistance. Disordered one-carbon metabolism during early development may increase later metabolic risk. We explored these associations in another birth cohort in India at three age points.

Methods

We measured plasma vitamin B12, folate and homocysteine concentrations at 30 ± 2 weeks' gestation in 654 women who delivered at one hospital. Neonatal anthropometry was recorded, and the children's glucose and insulin concentrations were measured at 5, 9.5 and 13.5 years of age. Insulin resistance was estimated using HOMA of

SUBMITTER: Krishnaveni GV 

PROVIDER: S-EPMC3855580 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature