Ontology highlight
ABSTRACT:
SUBMITTER: Ohno H
PROVIDER: S-EPMC3855638 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Ohno Haruya H Shinoda Kosaku K Ohyama Kana K Sharp Louis Z LZ Kajimura Shingo S
Nature 20131106 7478
Brown adipose tissue (BAT) dissipates chemical energy in the form of heat as a defence against hypothermia and obesity. Current evidence indicates that brown adipocytes arise from Myf5(+) dermotomal precursors through the action of PR domain containing protein 16 (PRDM16) transcriptional complex. However, the enzymatic component of the molecular switch that determines lineage specification of brown adipocytes remains unknown. Here we show that euchromatic histone-lysine N-methyltransferase 1 (EH ...[more]