Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC3855893 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Zhang Xiaobo X Lee Seong-Ho SH Min Kyung-Won KW McEntee Michael F MF Jeong Jin Boo JB Li Qingwang Q Baek Seung Joon SJ
Cancer prevention research (Philadelphia, Pa.) 20131008 12
The nonsteroidal anti-inflammatory drug tolfenamic acid has been shown to suppress cancer cell growth and tumorigenesis in different cancer models. However, the underlying mechanism by which tolfenamic acid exerts its antitumorigenic effect remains unclear. Previous data from our group and others indicate that tolfenamic acid alters expression of apoptosis- and cell-cycle arrest-related genes in colorectal cancer cells. Here, we show that tolfenamic acid markedly reduced the number of polyps and ...[more]