Ontology highlight
ABSTRACT:
SUBMITTER: Whitworth K
PROVIDER: S-EPMC3855908 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Whitworth Karen K Bradford Mary Katherine MK Camara Nicole N Wendland Beverly B
Traffic (Copenhagen, Denmark) 20131031 1
Pan1 is a multi-domain scaffold that enables dynamic interactions with both structural and regulatory components of the endocytic pathway. Pan1 is composed of Eps15 Homology (EH) domains which interact with adaptor proteins, a central region that is responsible for its oligomerization and C-terminal binding sites for Arp2/3, F-actin, and type-I myosin motors. In this study, we have characterized the binding sites between Pan1 and its constitutive binding partner End3, another EH domain containin ...[more]