Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC3856035 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Liu Jie J Li Jia J Zhang Jian-Fang JF Xin Xiao-Yan XY
International journal of molecular sciences 20131104 11
The combination of fenretinide and selenite on ovarian cancer cells was investigated to assess its effects on proliferation and ability to induce apoptosis. Our results showed that fenretinide and selenite in combination significantly suppress the proliferation of ovarian cancer cells and induced apoptosis (including reactive oxygen species generation, and the loss of mitochondrial membrane potential) compared with either drug used alone. The caspase3/9-dependent pathway was triggered significan ...[more]