Ontology highlight
ABSTRACT:
SUBMITTER: Agasti SS
PROVIDER: S-EPMC3856557 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Agasti Sarit S SS Laughney Ashley M AM Kohler Rainer H RH Weissleder Ralph R
Chemical communications (Cambridge, England) 20131201 94
We report here a method that utilizes a photoactivatable drug-caged fluorophore conjugate to quantify intracellular drug trafficking processes at single cell resolution. Photoactivation is performed in labeled cellular compartments to visualize intracellular drug exchange under physiological conditions, without the need for washing, facilitating its translation into in vivo cancer models. ...[more]