The modifying effect of C-reactive protein gene polymorphisms on the association between central obesity and endometrial cancer risk.

ABSTRACT:

Background

Obesity is a major risk factor for endometrial cancer. Obesity, particularly central obesity, is considered as a systemic inflammatory condition and is related strongly to insulin resistance. C-reactive protein (CRP) is the most recognized biologic marker of chronic systematic inflammation, and it is conceivable that the CRP gene may work together with obesity in the development of endometrial cancer.

Methods

On the basis of a population-based case-control study in a Chinese population, the authors obtained obesity measurements and data on 6 CRP single-nucleotide polymorphisms (SNPs) from 1046 patients with newly diagnosed endometrial cancer (cases) and from 1035 age frequency-matched controls. The association of the CRP SNPs with endometrial cancer risk and their

SUBMITTER: Wen W 

PROVIDER: S-EPMC3856630 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature