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Structures of hepatitis C virus nonstructural proteins required for replicase assembly and function.

ABSTRACT: Approximately 3% of the world population is infected with hepatitis C virus (HCV), causing a serious public health burden. Like other positive-strand RNA viruses, HCV assembles replicase complexes in association with cellular membranes and produces progeny RNA genomes through negative-strand intermediates. The viral proteins required for RNA replication are nonstructural (NS) proteins NS3 to NS5B. Owing to many obstacles and limitations in structural characterization of proteins and complexes with multiple transmembrane segments, attempts to understand the assembly and action of the HCV replicase complex have been challenging. Nevertheless, great progress has been made in obtaining structural information for several replicase components, providing insights into some aspects of the viral genome replication machinery.

SUBMITTER: Gu M

PROVIDER: S-EPMC3856683 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Structures of hepatitis C virus nonstructural proteins required for replicase assembly and function.

Gu Meigang M Rice Charles M CM

Current opinion in virology 20130416 2

Approximately 3% of the world population is infected with hepatitis C virus (HCV), causing a serious public health burden. Like other positive-strand RNA viruses, HCV assembles replicase complexes in association with cellular membranes and produces progeny RNA genomes through negative-strand intermediates. The viral proteins required for RNA replication are nonstructural (NS) proteins NS3 to NS5B. Owing to many obstacles and limitations in structural characterization of proteins and complexes wi ...[more]

PMID: 23601958

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