Ontology highlight
ABSTRACT:
SUBMITTER: Folgueras AR
PROVIDER: S-EPMC3856689 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Folgueras Alicia R AR Guo Xingyi X Pasolli H Amalia HA Stokes Nicole N Polak Lisa L Zheng Deyou D Fuchs Elaine E
Cell stem cell 20130901 3
In adult skin, self-renewing, undifferentiated hair follicle stem cells (HF-SCs) reside within a specialized niche, where they spend prolonged times as a single layer of polarized, quiescent epithelial cells. When sufficient activating signals accumulate, HF-SCs become mobilized to fuel tissue regeneration and hair growth. Here, we show that architectural organization of the HF-SC niche by transcription factor LHX2 plays a critical role in HF-SC behavior. Using genome-wide chromatin and transcri ...[more]