Ontology highlight
ABSTRACT:
SUBMITTER: Ahmadbeigi N
PROVIDER: S-EPMC3856940 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Ahmadbeigi Naser N Soleimani Masoud M Vasei Mohammad M Gheisari Yousof Y Mortazavi Yousef Y Azadmanesh Kayhan K Omidkhoda Azadeh A Janzamin Ehsan E Nardi Nance Beyer NB
Stem cells and development 20130914 23
Although the unique role of hematopoietic stem cell (HSC) niche in hematopoiesis has long been recognized, unsuccessful isolation of intact niche units limited their in vitro study, manipulation, and therapeutic application. Here, we isolated cell complexes based on size fractionation from mouse bone marrow (BM), characterized the derived cells, and transplanted them to irradiated mice. These cell complexes were the origin of both BM mesenchymal stem cells and various hematopoietic lineages when ...[more]