Radiation and smoking effects on lung cancer incidence among atomic bomb survivors.

ABSTRACT: While radiation increases the risk of lung cancer among members of the Life Span Study (LSS) cohort of atomic bomb survivors, there are still important questions about the nature of its interaction with smoking, the predominant cause of lung cancer. Among 105,404 LSS subjects, 1,803 primary lung cancer incident cases were identified for the period 1958-1999. Individual smoking history information and the latest radiation dose estimates were used to investigate the joint effects of radiation and smoking on lung cancer rates using Poisson grouped survival regression methods. Relative to never-smokers, lung cancer risks increased with the amount and duration of smoking and decreased with time since quitting smoking at any level of radiation exposure. Models assuming generalized interactions o

SUBMITTER: Furukawa K 

PROVIDER: S-EPMC3857029 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature