Ontology highlight
ABSTRACT:
SUBMITTER: Sir JH
PROVIDER: S-EPMC3857480 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
The Journal of cell biology 20131202 5
Most animal cells contain a centrosome, which comprises a pair of centrioles surrounded by an ordered pericentriolar matrix (PCM). Although the role of this organelle in organizing the mitotic spindle poles is well established, its precise contribution to cell division and cell survival remains a subject of debate. By genetically ablating key components of centriole biogenesis in chicken DT40 B cells, we generated multiple cell lines that lack centrioles. PCM components accumulated in acentriola ...[more]