Ontology highlight
ABSTRACT:
SUBMITTER: Rogers CD
PROVIDER: S-EPMC3857483 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
The Journal of cell biology 20131202 5
The neural crest, an embryonic stem cell population, initially resides within the dorsal neural tube but subsequently undergoes an epithelial-to-mesenchymal transition (EMT) to commence migration. Although neural crest and cancer EMTs are morphologically similar, little is known regarding conservation of their underlying molecular mechanisms. We report that Sip1, which is involved in cancer EMT, plays a critical role in promoting the neural crest cell transition to a mesenchymal state. Sip1 tran ...[more]