Ontology highlight
ABSTRACT:
SUBMITTER: Romao S
PROVIDER: S-EPMC3857489 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Romao Susana S Gasser Nathalie N Becker Andrea C AC Guhl Bruno B Bajagic Milica M Vanoaica Danusia D Ziegler Urs U Roesler Joachim J Dengjel Jörn J Reichenbach Janine J Münz Christian C
The Journal of cell biology 20131201 5
Antigen preservation for presentation is a hallmark of potent antigen-presenting cells. In this paper, we report that in human macrophages and dendritic cells, a subset of phagosomes gets coated with Atg8/LC3, a component of the molecular machinery of macroautophagy, and maintains phagocytosed antigens for prolonged presentation on major histocompatibility complex class II molecules. These Atg8/LC3-positive phagosomes are formed around the antigen with TLR2 agonists and require reactive oxygen s ...[more]