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Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing.


ABSTRACT: Antigen preservation for presentation is a hallmark of potent antigen-presenting cells. In this paper, we report that in human macrophages and dendritic cells, a subset of phagosomes gets coated with Atg8/LC3, a component of the molecular machinery of macroautophagy, and maintains phagocytosed antigens for prolonged presentation on major histocompatibility complex class II molecules. These Atg8/LC3-positive phagosomes are formed around the antigen with TLR2 agonists and require reactive oxygen species production by NOX2 for their generation. A deficiency in the NOX2-dependent formation of these antigen storage phagosomes could contribute to compromise antifungal immune control in chronic granulomatous disease patients.

SUBMITTER: Romao S 

PROVIDER: S-EPMC3857489 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing.

Romao Susana S   Gasser Nathalie N   Becker Andrea C AC   Guhl Bruno B   Bajagic Milica M   Vanoaica Danusia D   Ziegler Urs U   Roesler Joachim J   Dengjel Jörn J   Reichenbach Janine J   Münz Christian C  

The Journal of cell biology 20131201 5


Antigen preservation for presentation is a hallmark of potent antigen-presenting cells. In this paper, we report that in human macrophages and dendritic cells, a subset of phagosomes gets coated with Atg8/LC3, a component of the molecular machinery of macroautophagy, and maintains phagocytosed antigens for prolonged presentation on major histocompatibility complex class II molecules. These Atg8/LC3-positive phagosomes are formed around the antigen with TLR2 agonists and require reactive oxygen s  ...[more]

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