Unknown

Dataset Information

0

Serological and molecular characteristics of the first Korean case of Echinococcus multilocularis.


ABSTRACT: In December 2011, we reported an autochthonous case of Echinococcus multilocularis infection in a 42-year-old woman in Korea. The diagnosis was based on histopathological findings of the surgically resected liver cyst. In the present study, we evaluated the serological and molecular characteristics of this Korean E. multilocularis case. The patient's serum strongly reacted with affinity-purified native Em18 and recombinant Em18 antigens (specific for E. multilocularis) but negative for recombinant antigen B8/1 (reactive for Echinococcus granulosus). In immunoaffinity chromatography, the serum also strongly reacted with E. multilocularis and only weakly positive for E. granulosus. We determined the whole nucleotide sequence of cox1 (1,608 bp) using the paraffin-embedded cystic tissue which was compared with E. multilocularis isolates from China, Japan, Kazakhstan, Austria, France, and Slovakia. The Korean case showed 99.8-99.9% similarity with isolates from Asia (the highest similarity with an isolate from Sichuan, China), whereas the similarity with European isolates ranged from 99.5 to 99.6%.

SUBMITTER: Jeong JS 

PROVIDER: S-EPMC3857511 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Serological and molecular characteristics of the first Korean case of Echinococcus multilocularis.

Jeong Jin-Sook JS   Han Sang-Young SY   Kim Young-Hoon YH   Sako Yasuhito Y   Yanagida Tetsuya T   Ito Akira A   Chai Jong-Yil JY  

The Korean journal of parasitology 20131031 5


In December 2011, we reported an autochthonous case of Echinococcus multilocularis infection in a 42-year-old woman in Korea. The diagnosis was based on histopathological findings of the surgically resected liver cyst. In the present study, we evaluated the serological and molecular characteristics of this Korean E. multilocularis case. The patient's serum strongly reacted with affinity-purified native Em18 and recombinant Em18 antigens (specific for E. multilocularis) but negative for recombina  ...[more]

Similar Datasets

| S-EPMC5011620 | biostudies-literature
| S-EPMC356886 | biostudies-literature
| PRJNA860097 | ENA
| PRJDB3524 | ENA
| PRJNA213891 | ENA
| PRJNA308738 | ENA
| PRJNA388637 | ENA
| S-EPMC3367629 | biostudies-literature
| S-EPMC3291209 | biostudies-literature
| S-EPMC7789706 | biostudies-literature