Ontology highlight
ABSTRACT:
SUBMITTER: Willett BJ
PROVIDER: S-EPMC3857596 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Willett Brian J BJ Hosie Margaret J MJ
Current opinion in virology 20130828 6
The feline and human immunodeficiency viruses (FIV and HIV) target helper T cells selectively, and in doing so they induce a profound immune dysfunction. The primary determinant of HIV cell tropism is the expression pattern of the primary viral receptor CD4 and co-receptor(s), such as CXCR4 and CCR5. FIV employs a distinct strategy to target helper T cells; a high affinity interaction with CD134 (OX40) is followed by binding of the virus to its sole co-receptor, CXCR4. Recent studies have demons ...[more]