NMNATs, evolutionarily conserved neuronal maintenance factors.
Ontology highlight
ABSTRACT:
SUBMITTER: Ali YO
PROVIDER: S-EPMC3857727 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
NMNATs, evolutionarily conserved neuronal maintenance factors.
Ali Yousuf O YO Li-Kroeger David D Bellen Hugo J HJ Zhai R Grace RG Lu Hui-Chen HC
Trends in neurosciences 20130820 11
Proper brain function requires neuronal homeostasis over a range of environmental challenges. Neuronal activity, injury, and aging stress the nervous system, and lead to neuronal dysfunction and degeneration. Nevertheless, most organisms maintain healthy neurons throughout life, implying the existence of active maintenance mechanisms. Recent studies have revealed a key neuronal maintenance and protective function for nicotinamide mononucleotide adenylyl transferases (NMNATs). We review evidence ...[more]
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