Ontology highlight
ABSTRACT:
SUBMITTER: Qian L
PROVIDER: S-EPMC3857783 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Qian Liangyue L Yuan Fenghua F Rodriguez-Tello Paola P Padgaonkar Suyog S Zhang Yanbin Y
PloS one 20131204 12
In eukaryotic cells, Flap endonuclease 1 (FEN1) is a major structure-specific endonuclease that processes 5' flapped structures during maturation of lagging strand DNA synthesis, long patch base excision repair, and rescue of stalled replication forks. Here we report that fanconi anemia complementation group A protein (FANCA), a protein that recognizes 5' flap structures and is involved in DNA repair and maintenance of replication forks, constantly stimulates FEN1-mediated incision of both DNA a ...[more]