Ontology highlight
ABSTRACT:
SUBMITTER: Karimi MM
PROVIDER: S-EPMC3857791 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Karimi Mohammad M MM Goyal Preeti P Maksakova Irina A IA Bilenky Misha M Leung Danny D Tang Jie Xin JX Shinkai Yoichi Y Mager Dixie L DL Jones Steven S Hirst Martin M Lorincz Matthew C MC
Cell stem cell 20110601 6
DNA methylation and histone H3 lysine 9 trimethylation (H3K9me3) play important roles in silencing of genes and retroelements. However, a comprehensive comparison of genes and repetitive elements repressed by these pathways has not been reported. Here we show that in mouse embryonic stem cells (mESCs), the genes upregulated after deletion of the H3K9 methyltransferase Setdb1 are distinct from those derepressed in mESC deficient in the DNA methyltransferases Dnmt1, Dnmt3a, and Dnmt3b, with the ex ...[more]