Helicobacter pylori genomic microevolution during naturally occurring transmission between adults.
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ABSTRACT:
SUBMITTER: Linz B
PROVIDER: S-EPMC3858298 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Helicobacter pylori genomic microevolution during naturally occurring transmission between adults.
Linz Bodo B Windsor Helen M HM Gajewski John P JP Hake Caylie M CM Drautz Daniela I DI Schuster Stephan C SC Marshall Barry J BJ
PloS one 20131210 12
The human gastric pathogen Helicobacter pylori is usually acquired during childhood and, in the absence of treatment, chronic infection persists through most of the host's life. However, the frequency and importance of H. pylori transmission between adults is underestimated. Here we sequenced the complete genomes of H. pylori strains that were transmitted between spouses and analysed the genomic changes. Similar to H. pylori from chronic infection, a significantly high proportion of the determin ...[more]
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