Unknown

Dataset Information

0

Ala54Thr fatty acid-binding protein 2 (FABP2) polymorphism in recurrent depression: associations with fatty acid concentrations and waist circumference.


ABSTRACT:

Background

Fatty acid (FA)-alterations may mediate the mutual association between Major Depressive Disorder (MDD) and cardiovascular disease (CVD). However, etiology of observed FA-alterations in MDD and CVD remains largely unclear. An interesting candidate may be a mutation in the fatty acid-binding protein 2 (FABP2)-gene, because it regulates dietary FA-uptake. Therefore, we aimed to test the hypotheses that in MDD-patients the FABP2 Ala54Thr-polymorphism would be (I) more prevalent than in sex- and age-matched controls, (II) associated with observed alterations in FA-metabolism, and (III) associated with CVD-risk factor waist circumference.

Methods

We measured concentrations of 29 different erythrocyte FAs, FABP2-genotype, and waist circumference in recurrent MDD-patients and matched never-depressed controls.

Results

FABP2-genotype distribution did not significantly differ between the 137 MDD-patients and 73 matched controls. However, patients with the Ala54Thr-polymorphism had (I) higher concentrations of especially eicosadienoic acid (C20:2?6; P=.009) and other 20-carbon FAs, and associated (II) lower waist circumference (P=.019). In addition, FABP2-genotype effects on waist circumference in patients seemed (I) mediated by its effect on C20:2?6, and (II) different from controls.

Conclusions

Although Ala54Thr-polymorphism distribution was not associated with recurrent MDD, our results indicate that FABP2 may play a role in the explanation of observed FA-alterations in MDD. For Ala54Thr-polymorphism patients, potentially adaptive conversion of increased bioavailable dietary precursors into eicosadienoic acid instead of arachidonic acid might be related to a low waist circumference. Because this is the first investigation of these associations, replication is warranted, preferably by nutrigenetic studies applying lipidomics and detailed dietary assessment.

SUBMITTER: Mocking RJ 

PROVIDER: S-EPMC3858331 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

altmetric image

Publications

Ala54Thr fatty acid-binding protein 2 (FABP2) polymorphism in recurrent depression: associations with fatty acid concentrations and waist circumference.

Mocking Roel J T RJ   Lok Anja A   Assies Johanna J   Koeter Maarten W J MW   Visser Ieke I   Ruhé Henricus G HG   Bockting Claudi L H CL   Schene Aart H AH  

PloS one 20131210 12


<h4>Background</h4>Fatty acid (FA)-alterations may mediate the mutual association between Major Depressive Disorder (MDD) and cardiovascular disease (CVD). However, etiology of observed FA-alterations in MDD and CVD remains largely unclear. An interesting candidate may be a mutation in the fatty acid-binding protein 2 (FABP2)-gene, because it regulates dietary FA-uptake. Therefore, we aimed to test the hypotheses that in MDD-patients the FABP2 Ala54Thr-polymorphism would be (I) more prevalent th  ...[more]

Similar Datasets

| S-EPMC8305881 | biostudies-literature
| S-EPMC4730443 | biostudies-literature
| S-EPMC4302657 | biostudies-literature
| S-EPMC4795721 | biostudies-literature
| S-EPMC5859081 | biostudies-literature
| S-EPMC9381319 | biostudies-literature
| S-EPMC3933952 | biostudies-literature
| S-EPMC6441458 | biostudies-literature
| S-EPMC10498546 | biostudies-literature
| S-EPMC5662154 | biostudies-literature