Dataset Information

Economic evaluation of first-line adjuvant chemotherapies for resectable gastric cancer patients in China.

ABSTRACT:

Background

First-line postoperative adjuvant chemotherapies with S-1 and capecitabine and oxaliplatin (XELOX) were first recommended for resectable gastric cancer patients in the 2010 and 2011 Chinese NCCN Clinical Practice Guidelines in Oncology: Gastric Cancer; however, their economic impact in China is unknown.

Objective

The aim of this study was to compare the cost-effectiveness of adjuvant chemotherapy with XELOX, with S-1 and no treatment after a gastrectomy with extended (D2) lymph-node dissection among patients with stage II-IIIB gastric cancer.

Methods

A Markov model, based on data from two clinical phase III trials, was developed to analyse the cost-effectiveness of patients in the XELOX group, S-1 group and surgery only (SO) group. The costs were estimated from the perspective of Chinese healthcare system. The utilities were assumed on the basis of previously published reports. Costs, quality-adjusted life-years (QALYs) and incremental cost-effectiveness ratios (ICER) were calculated with a lifetime horizon. One-way and probabilistic sensitivity analyses were performed.

Results

For the base case, XELOX had the lowest total cost ($44,568) and cost-effectiveness ratio ($7,360/QALY). The relative scenario analyses showed that SO was dominated by XELOX and the ICERs of S-1 was $58,843/QALY compared with XELOX. The one-way sensitivity analysis showed that the most influential parameter was the utility of disease-free survival. The probabilistic sensitivity analysis predicted a 75.8% likelihood that the ICER for XELOX would be less than $13,527 compared with S-1. When ICER was more than $38,000, the likelihood of cost-effectiveness achieved by S-1 group was greater than 50%.

Conclusions

Our results suggest that for patients in China with resectable disease, first-line adjuvant chemotherapy with XELOX after a D2 gastrectomy is a best option comparing with S-1 and SO in view of our current study. In addition, S-1 might be a better choice, especially with a higher value of willingness-to-pay threshold.

SUBMITTER: Tan C

PROVIDER: S-EPMC3858361 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

Economic evaluation of first-line adjuvant chemotherapies for resectable gastric cancer patients in China.

Tan Chongqing C Peng Liubao L Zeng Xiaohui X Li Jianhe J Wan Xiaomin X Chen Gannong G Yi Lidan L Luo Xia X Zhao Ziying Z

PloS one 20131210 12

<h4>Background</h4>First-line postoperative adjuvant chemotherapies with S-1 and capecitabine and oxaliplatin (XELOX) were first recommended for resectable gastric cancer patients in the 2010 and 2011 Chinese NCCN Clinical Practice Guidelines in Oncology: Gastric Cancer; however, their economic impact in China is unknown.<h4>Objective</h4>The aim of this study was to compare the cost-effectiveness of adjuvant chemotherapy with XELOX, with S-1 and no treatment after a gastrectomy with extended (D ...[more]

PMID: 24340099

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Dataset Information

Economic evaluation of first-line adjuvant chemotherapies for resectable gastric cancer patients in China.

Background

Objective

Methods

Results

Conclusions

Publications

Economic evaluation of first-line adjuvant chemotherapies for resectable gastric cancer patients in China.

Similar Datasets

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