Ontology highlight
ABSTRACT:
SUBMITTER: Mendenhall EM
PROVIDER: S-EPMC3858395 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Mendenhall Eric M EM Williamson Kaylyn E KE Reyon Deepak D Zou James Y JY Ram Oren O Joung J Keith JK Bernstein Bradley E BE
Nature biotechnology 20130908 12
Mammalian gene regulation is dependent on tissue-specific enhancers that can act across large distances to influence transcriptional activity. Mapping experiments have identified hundreds of thousands of putative enhancers whose functionality is supported by cell type-specific chromatin signatures and striking enrichments for disease-associated sequence variants. However, these studies did not address the in vivo functions of the putative elements or their chromatin states and did not determine ...[more]