Ontology highlight
ABSTRACT:
SUBMITTER: Gutierrez-de-Teran H
PROVIDER: S-EPMC3858454 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20131107 12
The function of G protein-coupled receptors (GPCRs) can be modulated by a number of endogenous allosteric molecules. In this study, we used molecular dynamics, radioligand binding, and thermostability experiments to elucidate the role of the recently discovered sodium ion binding site in the allosteric modulation of the human A(2A) adenosine receptor, conserved among class A GPCRs. While the binding of antagonists and sodium ions to the receptor was noncompetitive in nature, the binding of agoni ...[more]