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Cerebral aneurysms treated with flow-diverting stents: computational models with intravascular blood flow measurements.


ABSTRACT: BACKGROUND AND PURPOSE:Computational fluid dynamics modeling is useful in the study of the hemodynamic environment of cerebral aneurysms, but patient-specific measurements of boundary conditions, such as blood flow velocity and pressure, have not been previously applied to the study of flow-diverting stents. We integrated patient-specific intravascular blood flow velocity and pressure measurements into computational models of aneurysms before and after treatment with flow-diverting stents to determine stent effects on aneurysm hemodynamics. MATERIALS AND METHODS:Blood flow velocity and pressure were measured in peri-aneurysmal locations by use of an intravascular dual-sensor pressure and Doppler velocity guidewire before and after flow-diverting stent treatment of 4 unruptured cerebral aneurysms. These measurements defined inflow and outflow boundary conditions for computational models. Intra-aneurysmal flow rates, wall shear stress, and wall shear stress gradient were calculated. RESULTS:Measurements of inflow velocity and outflow pressure were successful in all 4 patients. Computational models incorporating these measurements demonstrated significant reductions in intra-aneurysmal wall shear stress and wall shear stress gradient and a trend in reduced intra-aneurysmal blood flow. CONCLUSIONS:Integration of intravascular dual-sensor guidewire measurements of blood flow velocity and blood pressure provided patient-specific computational models of cerebral aneurysms. Aneurysm treatment with flow-diverting stents reduces blood flow and hemodynamic shear stress in the aneurysm dome.

SUBMITTER: Levitt MR 

PROVIDER: S-EPMC3858573 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Cerebral aneurysms treated with flow-diverting stents: computational models with intravascular blood flow measurements.

Levitt M R MR   McGah P M PM   Aliseda A A   Mourad P D PD   Nerva J D JD   Vaidya S S SS   Morton R P RP   Ghodke B V BV   Kim L J LJ  

AJNR. American journal of neuroradiology 20130718 1


<h4>Background and purpose</h4>Computational fluid dynamics modeling is useful in the study of the hemodynamic environment of cerebral aneurysms, but patient-specific measurements of boundary conditions, such as blood flow velocity and pressure, have not been previously applied to the study of flow-diverting stents. We integrated patient-specific intravascular blood flow velocity and pressure measurements into computational models of aneurysms before and after treatment with flow-diverting stent  ...[more]

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