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Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs.

ABSTRACT: The synthesis of an isosteric analog of the natural product and HDAC inhibitor largazole is described. The sulfur atom in the thizaole ring of the natural product has been replaced with an oxygen atom, constituting an oxazole ring. The biochemical activity and cytotoxicity of this species is described.

SUBMITTER: Guerra-Bubb JM

PROVIDER: S-EPMC3859309 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs.

Guerra-Bubb Jennifer M JM Bowers Albert A AA Smith William B WB Paranal Ronald R Estiu Guillermina G Wiest Olaf O Bradner James E JE Williams Robert M RM

Bioorganic & medicinal chemistry letters 20130618 21

The synthesis of an isosteric analog of the natural product and HDAC inhibitor largazole is described. The sulfur atom in the thizaole ring of the natural product has been replaced with an oxygen atom, constituting an oxazole ring. The biochemical activity and cytotoxicity of this species is described. ...[more]

PMID: 24035339

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Multifunctional Isosteric Pyridine Analogs-Based 2-Aminothiazole: Design, Synthesis, and Potential Phosphodiesterase-5 Inhibitory Activity.

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