Ontology highlight
ABSTRACT:
SUBMITTER: Montalvao F
PROVIDER: S-EPMC3859399 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Montalvao Fabricio F Garcia Zacarias Z Celli Susanna S Breart Béatrice B Deguine Jacques J Van Rooijen Nico N Bousso Philippe P
The Journal of clinical investigation 20131101 12
Anti-CD20 Ab therapy has proven successful for treating B cell malignancies and a number of autoimmune diseases. However, how anti-CD20 Abs operate in vivo to mediate B cell depletion is not fully understood. In particular, the anatomical location, the type of effector cells, and the mechanism underlying anti-CD20 therapy remain uncertain. Here, we found that the liver is a major site for B cell depletion and that recirculation accounts for the decrease in B cell numbers observed in secondary ly ...[more]