Ontology highlight
ABSTRACT:
SUBMITTER: Nie L
PROVIDER: S-EPMC3859420 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Nie Lei L Guo Xiaojia X Esmailzadeh Leila L Zhang Jiasheng J Asadi Abolfazl A Collinge Mark M Li Xuan X Kim Jun-Dae JD Woolls Melissa M Jin Suk-Won SW Dubrac Alexandre A Eichmann Anne A Simons Michael M Bender Jeffrey R JR Sadeghi Mehran M MM
The Journal of clinical investigation 20131101 12
Aberrant blood vessel formation contributes to a wide variety of pathologies, and factors that regulate angiogenesis are attractive therapeutic targets. Endothelial and smooth muscle cell-derived neuropilin-like protein (ESDN) is a neuropilin-related transmembrane protein expressed in ECs; however, its potential effect on VEGF responses remains undefined. Here, we generated global and EC-specific Esdn knockout mice and demonstrated that ESDN promotes VEGF-induced human and murine EC proliferatio ...[more]