Ontology highlight
ABSTRACT:
SUBMITTER: Di Penta A
PROVIDER: S-EPMC3859644 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Di Penta Alessandra A Chiba Asako A Alloza Iraide I Wyssenbach Ane A Yamamura Takashi T Villoslada Pablo P Miyake Sachiko S Vandenbroeck Koen K
PloS one 20131211 12
Celecoxib is a selective cyclooxygenase-2 (COX2) inhibitor. We have previously shown that celecoxib inhibits experimental autoimmune encephalomyelitis (EAE) in COX-2-deficient mice, suggestive for a mode of action involving COX2-independent pathways. In the present study, we tested the effect of a trifluoromethyl analogue of celecoxib (TFM-C) with 205-fold lower COX-2 inhibitory activity in two models of neuroinflammation, i.e. cerebellar organotypic cultures challenged with LPS and the EAE mous ...[more]