Angiotensin converting enzyme-inhibitor reduces colitis severity in an IL-10 knockout model.

ABSTRACT:

Background

We previously demonstrated angiotensin converting enzymes (ACE) over-expression in a dextran-sodium sulfate colitis model; ACE inhibitor (ACE-I) treatment reduced colitis severity in this model. However, ACE-I has not been tested in more immunologically relevant colitis models.

Aim

We hypothesized that ACE-I would decrease disease severity in an IL-10 knockout (-/-) colitis model.

Methods

Colitis was induced by giving 10-week old IL-10-/- mice piroxicam (P.O.) for 14 days. The ACE-I enalaprilat was given transanally at a dose of 6.25 mg/kg for 21 days. Prednisolone (PSL) with or without enalaprilat were used as therapeutic, comparative groups. All groups were compared to a placebo treated group. Outcome measures were clinical course, histology, abundance of

SUBMITTER: Sueyoshi R 

PROVIDER: S-EPMC3859685 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature