Antimicrobial efflux pumps and Mycobacterium tuberculosis drug tolerance: evolutionary considerations.
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ABSTRACT:
SUBMITTER: Szumowski JD
PROVIDER: S-EPMC3859842 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Antimicrobial efflux pumps and Mycobacterium tuberculosis drug tolerance: evolutionary considerations.
Szumowski John D JD Adams Kristin N KN Edelstein Paul H PH Ramakrishnan Lalita L
Current topics in microbiology and immunology 20130101
The need for lengthy treatment to cure tuberculosis stems from phenotypic drug resistance, also known as drug tolerance, which has been previously attributed to slowed bacterial growth in vivo. We discuss recent findings that challenge this model and instead implicate macrophage-induced mycobacterial efflux pumps in antimicrobial tolerance. Although mycobacterial efflux pumps may have originally served to protect against environmental toxins, in the pathogenic mycobacteria, they appear to have b ...[more]
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