Ontology highlight
ABSTRACT:
SUBMITTER: Pavlopoulou A
PROVIDER: S-EPMC3859875 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Pavlopoulou Athanasia A Vlachakis Dimitrios D Balatsos Nikolaos A A NA Kossida Sophia S
Evolutionary bioinformatics online 20131202
Deadenylases catalyze the shortening of the poly(A) tail at the messenger ribonucleic acid (mRNA) 3'-end in eukaryotes. Therefore, these enzymes influence mRNA decay, and constitute a major emerging group of promising anti-cancer pharmacological targets. Herein, we conducted full phylogenetic analyses of the deadenylase homologs in all available genomes in an effort to investigate evolutionary relationships between the deadenylase families and to identify invariant residues, which probably play ...[more]