Ontology highlight
ABSTRACT:
SUBMITTER: Black JC
PROVIDER: S-EPMC3861058 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Black Joshua C JC Van Rechem Capucine C Whetstine Johnathan R JR
Molecular cell 20121101 4
Histone lysine methylation has emerged as a critical player in the regulation of gene expression, cell cycle, genome stability, and nuclear architecture. Over the past decade, a tremendous amount of progress has led to the characterization of methyl modifications and the lysine methyltransferases (KMTs) and lysine demethylases (KDMs) that regulate them. Here, we review the discovery and characterization of the KMTs and KDMs and the methyl modifications they regulate. We discuss the localization ...[more]