Ontology highlight
ABSTRACT:
SUBMITTER: Auton A
PROVIDER: S-EPMC3861134 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Auton Adam A Rui Li Ying Y Kidd Jeffrey J Oliveira Kyle K Nadel Julie J Holloway J Kim JK Hayward Jessica J JJ Cohen Paula E PE Greally John M JM Wang Jun J Wang Jun J Bustamante Carlos D CD Boyko Adam R AR
PLoS genetics 20131212 12
The identification of the H3K4 trimethylase, PRDM9, as the gene responsible for recombination hotspot localization has provided considerable insight into the mechanisms by which recombination is initiated in mammals. However, uniquely amongst mammals, canids appear to lack a functional version of PRDM9 and may therefore provide a model for understanding recombination that occurs in the absence of PRDM9, and thus how PRDM9 functions to shape the recombination landscape. We have constructed a fine ...[more]