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Corticosteroids for dengue - why don't they work?

ABSTRACT:

Background

Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue.

Findings

In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. Prominent among the 81 transcripts were those associated with T and NK cell cytolytic functions. Additionally, prednisolone therapy was not associated with changes in plasma cytokine levels.

Conclusion

The inability of prednisolone treatment to markedly attenuate the host immune response is instructive for planning future therapeutic strategies for dengue.

SUBMITTER: Nguyen TH

PROVIDER: S-EPMC3861232 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

Corticosteroids for dengue - why don't they work?

Nguyen Thi Hanh Tien TH Nguyen Than Ha Quyen TH Vu Tuan Trung TT Farrar Jeremy J Hoang Truong Long TL Dong Thi Hoai Tam TH Ngoc Tran Van V Phung Khanh Lam KL Wolbers Marcel M Whitehead Stephen S SS Hibberd Martin L ML Wills Bridget B Simmons Cameron P CP

PLoS neglected tropical diseases 20131212 12

<h4>Background</h4>Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue.<h4>Findings</h4>In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. Prominent among the 81 transcripts were those associated with T and NK ...[more]

PMID: 24349598

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