Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC3861522 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Li Xiaopeng X Rossen Nathan N Sinn Patrick L PL Hornick Andrew L AL Steines Benjamin R BR Karp Philip H PH Ernst Sarah E SE Adam Ryan J RJ Moninger Thomas O TO Levasseur Dana N DN Zabner Joseph J
PloS one 20131212 12
To develop stem/progenitor cell-based therapy for cystic fibrosis (CF) lung disease, it is first necessary to identify markers of human lung epithelial progenitor/stem cells and to better understand the potential for differentiation into distinct lineages. Here we investigated integrin α6β4 as an epithelial progenitor cell marker in the human distal lung. We identified a subpopulation of α6β4(+) cells that localized in distal small airways and alveolar walls and were devoid of pro-surfactant pro ...[more]