Ontology highlight
ABSTRACT:
SUBMITTER: Seto S
PROVIDER: S-EPMC3862771 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Seto Shintaro S Sugaya Keiko K Tsujimura Kunio K Nagata Toshi T Horii Toshinobu T Koide Yukio Y
PloS one 20131213 12
Rab39a has pleiotropic functions in phagosome maturation, inflammatory activation and neuritogenesis. Here, we characterized Rab39a function in membrane trafficking of phagocytosis and autophagy induction in macrophages. Rab39a localized to the periphery of LAMP2-positive vesicles and showed the similar kinetics on the phagosome to that of LAMP1. The depletion of Rab39a did not influence the localization of LAMP2 to the phagosome, but it augments the autophagosome formation and LC3 processing by ...[more]