Folding of 16S rRNA in a signal-producing structure for the detection of bacteria.
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ABSTRACT:
SUBMITTER: Gerasimova YV
PROVIDER: S-EPMC3863991 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
Folding of 16S rRNA in a signal-producing structure for the detection of bacteria.
Gerasimova Yulia V YV Kolpashchikov Dmitry M DM
Angewandte Chemie (International ed. in English) 20130903 40
Sixty-four DNA strands hybridize to 16S rRNA to form 32 deoxyribozyme catalytic cores that produce a fluorescent signal. The approach allows detection of 0.6 pM 16S rRNA, or about 3×10(4) bacterial cells in a PCR-free format. ...[more]
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