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Pressure-controlled motion of single polymers through solid-state nanopores.

ABSTRACT: Voltage-biased solid-state nanopores are well established in their ability to detect and characterize single polymers, such as DNA, in electrolytes. The addition of a pressure gradient across the nanopore yields a second molecular driving force that provides new freedom for studying molecules in nanopores. In this work, we show that opposing pressure and voltage bias enables nanopores to detect and resolve very short DNA molecules, as well as to detect near-neutral polymers.

SUBMITTER: Lu B

PROVIDER: S-EPMC3864131 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Pressure-controlled motion of single polymers through solid-state nanopores.

Lu Bo B Hoogerheide David P DP Zhao Qing Q Zhang Hengbin H Tang Zhipeng Z Yu Dapeng D Golovchenko Jene A JA

Nano letters 20130628 7

Voltage-biased solid-state nanopores are well established in their ability to detect and characterize single polymers, such as DNA, in electrolytes. The addition of a pressure gradient across the nanopore yields a second molecular driving force that provides new freedom for studying molecules in nanopores. In this work, we show that opposing pressure and voltage bias enables nanopores to detect and resolve very short DNA molecules, as well as to detect near-neutral polymers. ...[more]

PMID: 23802688

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