Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC3864303 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Chen Zhaochun Z Fischer Elizabeth R ER Kouiavskaia Diana D Hansen Bryan T BT Ludtke Steven J SJ Bidzhieva Bella B Makiya Michelle M Agulto Liane L Purcell Robert H RH Chumakov Konstantin K
Proceedings of the National Academy of Sciences of the United States of America 20131125 50
Most structural information about poliovirus interaction with neutralizing antibodies was obtained in the 1980s in studies of mouse monoclonal antibodies. Recently we have isolated a number of human/chimpanzee anti-poliovirus antibodies and demonstrated that one of them, MAb A12, could neutralize polioviruses of both serotypes 1 and 2. This communication presents data on isolation of an additional cross-neutralizing antibody (F12) and identification of a previously unknown epitope on the surface ...[more]