Ontology highlight
ABSTRACT:
SUBMITTER: Kohnke M
PROVIDER: S-EPMC3864799 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Köhnke Monika M Delon Christine C Hastie Marcus L ML Nguyen Uyen T T UT Wu Yao-Wen YW Waldmann Herbert H Goody Roger S RS Gorman Jeffrey J JJ Alexandrov Kirill K
PloS one 20131216 12
Protein prenylation is a widespread post-translational modification in eukaryotes that plays a crucial role in membrane targeting and signal transduction. RabGTPases is the largest group of post-translationally C-terminally geranylgeranylated. All Rabs are processed by Rab geranylgeranyl-transferase and Rab escort protein (REP). Human genetic defects resulting in the loss one of two REP isoforms REP-1, lead to underprenylation of RabGTPases that manifests in retinal degradation and blindness kno ...[more]