Ontology highlight
ABSTRACT: Purpose
To assess the associations between cruciferous vegetable (CV) intake, GST gene polymorphisms, and colorectal cancer (CRC) in a population of Chinese men.Methods
Using incidence density sampling, CRC cases (N = 340) diagnosed before December 31, 2010 within the Shanghai Men's Health Study were matched to noncases (N = 673). CV intake was assessed from a food frequency questionnaire and by isothiocyanate levels from spot urine samples. GSTM1 and GSTT1 were categorized as null (0 copies) versus non-null (1 or 2 copies). Conditional logistic regression was used to calculate odds ratios and 95% confidence intervals for the association between CV intake and GST gene variants with CRC, and statistical interactions were evaluated.Results
CRC risk was not associated with CV intake, whether measured by self-report or by urinary isothiocyanate nor with GST gene variants. No statistical interactions were detected between CV intake and GST gene variants on the odds of CRC. Stratifying by timing of urine sample collection and excluding CRC cases diagnosed in the first 2 years did not materially alter the results.Conclusions
This study provides no evidence supporting the involvement of CV intake in the development of CRC in Chinese men.
SUBMITTER: Vogtmann E
PROVIDER: S-EPMC3864981 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Vogtmann Emily E Xiang Yong-Bing YB Li Hong-Lan HL Cai Quiyin Q Wu Qi-Jun QJ Xie Li L Li Guo-Liang GL Yang Gong G Waterbor John W JW Levitan Emily B EB Zhang Bin B Zheng Wei W Shu Xiao-Ou XO
Annals of epidemiology 20131012 1
<h4>Purpose</h4>To assess the associations between cruciferous vegetable (CV) intake, GST gene polymorphisms, and colorectal cancer (CRC) in a population of Chinese men.<h4>Methods</h4>Using incidence density sampling, CRC cases (N = 340) diagnosed before December 31, 2010 within the Shanghai Men's Health Study were matched to noncases (N = 673). CV intake was assessed from a food frequency questionnaire and by isothiocyanate levels from spot urine samples. GSTM1 and GSTT1 were categorized as nu ...[more]