Ontology highlight
ABSTRACT:
SUBMITTER: Enomoto T
PROVIDER: S-EPMC3865152 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Enomoto Takashi T Ohashi Koji K Shibata Rei R Kambara Takahiro T Uemura Yusuke Y Yuasa Daisuke D Kataoka Yoshiyuki Y Miyabe Megumi M Matsuo Kazuhiro K Joki Yusuke Y Hayakawa Satoko S Hiramatsu-Ito Mizuho M Ito Masanori M Murohara Toyoaki T Ouchi Noriyuki N
PloS one 20131216 12
Obese states characterized by chronic inflammation are closely linked to the development of metabolic dysfunction. We identified adipolin/CTRP12 as an insulin-sensitizing and anti-inflammatory adipokine. Although obese conditions down-regulate adipolin expression, its molecular mechanism is largely unknown. Here we show that the transcriptional regulator Krüppel-like factor (KLF) 15 is involved in the regulation of adipolin expression in adipocytes. White adipose tissue from diet-induced obese ( ...[more]