Ontology highlight
ABSTRACT:
SUBMITTER: Passarelli MN
PROVIDER: S-EPMC3865220 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Passarelli Michael N MN Newcomb Polly A PA Makar Karen W KW Burnett-Hartman Andrea N AN Phipps Amanda I AI David Sean P SP Hsu Li L Harrison Tabitha A TA Hutter Carolyn M CM Duggan David J DJ White Emily E Chan Andrew T AT Peters Ulrike U
Menopause (New York, N.Y.) 20140401 4
<h4>Objective</h4>Sex steroid hormones play a role in colorectal cancer (CRC) development, but little is known about their influence on tumor progression and metastasis. Because catechol-O-methyltransferase (COMT; 22q11.21) activity is an important component of estrogen-mediated carcinogenesis, we hypothesized that germline variation in COMT may be associated with CRC survival.<h4>Methods</h4>We identified 10 single nucleotide polymorphisms that tagged variation across two isoforms of COMT in 2, ...[more]