Ontology highlight
ABSTRACT:
SUBMITTER: Barbieri E
PROVIDER: S-EPMC3865347 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Barbieri Eveline E De Preter Katleen K Capasso Mario M Johansson Peter P Man Tsz-Kwong TK Chen Zaowen Z Stowers Paris P Tonini Gian Paolo GP Speleman Frank F Shohet Jason M JM
PloS one 20131119 11
Chemotherapy induces apoptosis and tumor regression primarily through activation of p53-mediated transcription. Neuroblastoma is a p53 wild type malignancy at diagnosis and repression of p53 signaling plays an important role in its pathogenesis. Recently developed small molecule inhibitors of the MDM2-p53 interaction are able to overcome this repression and potently activate p53 dependent apoptosis in malignancies with intact p53 downstream signaling. We used the small molecule MDM2 inhibitor, N ...[more]